X0407 4 2023-04-13 0 0001505512 Regulus Therapeutics Inc. RGLS 0001202098 PAPADOPOULOS STELIOS C/O REGULUS THERAPEUTICS INC. 4224 CAMPUS POINT COURT #210 SAN DIEGO CA 92121 1 0 0 0 0 Common Stock 2023-04-13 4 A 0 222198 0.9001 A 728388 D The securities were acquired from the Issuer pursuant to a Securities Purchase Agreement dated April 13, 2023. The Securities Purchase Agreement and the issuance of the securities thereunder was approved by the Issuer's Board of Directors and an independent committee thereof Adjusted to reflect 10-to-1 reverse stock split effected June 28, 2022. Christopher Aker, Attorney in Fact 2023-04-14