X0306 4 2019-12-24 0 0001505512 Regulus Therapeutics Inc. RGLS 0001703723 Witz Pascale C/O REGULUS THERAPEUTICS INC. 10628 SCIENCE CENTER DR., #225 SAN DIEGO CA 92121 1 0 0 0 Class A-2 Convertible Preferred Stock 2019-12-24 4 A 0 6770 6.66 A Common Stock 67700 6770 D Common Stock Purchase Warrant (Right to Buy) 0.666 2019-12-24 4 A 0 67700 0.125 A 2019-12-24 2024-12-24 Common Stock 67700 67700 D The shares of Class A-2 Convertible Preferred Stock have no expiration date and are convertible at any time at the election of the holder into shares of Common Stock without payment of further consideration. Each share of Class A-2 Convertible Preferred Stock converts into 10 shares of Common Stock. The securities were acquired from the issuer pursuant to a Securities Purchase Agreement dated May 3, 2019. The Securities Purchase Agreement and the issuance of the securities thereunder were approved by the Issuer's Board of Directors and an independent committee thereof. Christopher Aker, Attorney in Fact 2019-12-26