X0306 4 2019-10-10 0 0001505512 Regulus Therapeutics Inc. RGLS 0001703723 Witz Pascale C/O REGULUS THERAPEUTICS INC. 10628 SCIENCE CENTER DR., #225 SAN DIEGO CA 92121 1 0 0 0 Stock Option (Right to Buy) 0.64 2019-10-10 4 A 0 46500 0.00 A 2029-10-09 Common Stock 46500 46500 D The options will vest ratably over the following twelve months such that the option will be fully vested one year after the date of grant or on the date of the Company's next annual shareholder meeting, whichever occurs first, subject to the Reporting Person's continuous service. Christopher Aker, Attorney in Fact 2019-10-15