X0206 3 2019-08-30 1 0001505512 Regulus Therapeutics Inc. RGLS 0001606833 CALSADA CRISPINA C/O REGULUS THERAPEUTICS 10628 SCIENCE CENTER DR. #225 SAN DIEGO CA 92121 0 1 0 0 Chief Financial Officer Christopher Aker, Attorney in Fact 2019-09-03