Document Format Files
Seq | Description | Document | Type | Size |
---|---|---|---|---|
1 | FORM S-1 | d392345ds1.htm | S-1 | 2233432 |
2 | FORM OF UNDERWRITING AGREEMENT | d392345dex11.htm | EX-1.1 | 163964 |
3 | AMENDED AND RESTATED CERTIFICATE OF INCORPORATION | d392345dex31.htm | EX-3.1 | 88622 |
4 | BYLAWS | d392345dex33.htm | EX-3.3 | 171604 |
5 | FORM OF AMENDED AND RESTATED BYLAWS | d392345dex34.htm | EX-3.4 | 118161 |
6 | FORM OF COMMON STOCK CERTIFICATE | d392345dex41.htm | EX-4.1 | 10144 |
7 | FORM OF INDEMNITY AGREEMENT | d392345dex101.htm | EX-10.1 | 48273 |
8 | 2009 EQUITY INCENTIVE PLAN AND FORM OF STOCK OPTION GRANT NOTICE | d392345dex102.htm | EX-10.2 | 181626 |
9 | 2012 EQUITY INCENTIVE PLAN AND FORM OF STOCK OPTION AGREEMENT | d392345dex103.htm | EX-10.3 | 208850 |
10 | NON-EMPLOYEE DIRECTOR COMPENSATION POLICY | d392345dex104.htm | EX-10.4 | 11095 |
11 | 2012 EMPLOYEE STOCK PURCHASE PLAN | d392345dex105.htm | EX-10.5 | 56455 |
12 | AMENDED AND RESTATED EMPLOYMENT AGREEMENT | d392345dex106.htm | EX-10.6 | 68088 |
13 | AMENDED AND RESTATED EMPLOYMENT AGREEMENT | d392345dex107.htm | EX-10.7 | 66974 |
14 | EMPLOYMENT AGREEMENT | d392345dex108.htm | EX-10.8 | 66146 |
15 | LEASE | d392345dex109.htm | EX-10.9 | 326518 |
16 | FIRST AMENDMENT TO LEASE | d392345dex1010.htm | EX-10.10 | 11470 |
17 | SECOND AMENDMENT TO LEASE | d392345dex1011.htm | EX-10.11 | 27325 |
18 | THIRD AMENDMENT TO LEASE | d392345dex1012.htm | EX-10.12 | 26378 |
19 | FOUNDING INVESTOR RIGHTS AGREEMENT | d392345dex1013.htm | EX-10.13 | 177230 |
20 | AMENDMENT NUMBER ONE TO THE FOUNDING INVESTOR RIGHTS AGREEMENT | d392345dex1014.htm | EX-10.14 | 9170 |
21 | AMENDMENT NUMBER TWO TO THE FOUNDING INVESTOR RIGHTS AGREEMENT | d392345dex1015.htm | EX-10.15 | 10974 |
22 | INVESTOR RIGHTS AGREEMENT | d392345dex1016.htm | EX-10.16 | 93612 |
23 | AMENDED AND RESTATED LICENSE AND COLLABORATION AGREEMENT | d392345dex1017.htm | EX-10.17 | 2088782 |
24 | AMENDMENT NUMBER ONE TO THE AMENDED & RESTATED LICENSE & COLLABORATION AGREEMENT | d392345dex1018.htm | EX-10.18 | 20104 |
25 | AMENDMENT NUMBER TWO TO THE AMENDED & RESTATED LICENSE & COLLABORATION AGREEMENT | d392345dex1019.htm | EX-10.19 | 30128 |
26 | PRODUCT DEVELOPMENT AND COMMERCIALIZATION AGREEMENT | d392345dex1020.htm | EX-10.20 | 565764 |
27 | AMENDMENT #1 TO THE PRODUCT DEVELOPEMENT AND COMMERCIALIZATION AGREEMENT | d392345dex1021.htm | EX-10.21 | 116946 |
28 | AMENDMENT #2 TO THE PRODUCT DEVELOPEMENT AND COMMERCIALIZATION AGREEMENT | d392345dex1022.htm | EX-10.22 | 21019 |
29 | AMENDMENT #3 TO THE PRODUCT DEVELOPEMENT AND COMMERCIALIZATION AGREEMENT | d392345dex1023.htm | EX-10.23 | 14472 |
30 | EXCLUSIVE LICENSE AND NONEXCLUSIVE OPTION AGREEMENT | d392345dex1024.htm | EX-10.24 | 231408 |
31 | CO-EXCLUSIVE LICENSE AGREEMENT | d392345dex1025.htm | EX-10.25 | 114465 |
32 | ASSIGNMENT AGREEMENT | d392345dex1026.htm | EX-10.26 | 11953 |
33 | LICENSE AGREEMENT | d392345dex1027.htm | EX-10.27 | 140972 |
34 | AMENDED AND RESTATED LICENSE AGREEMENT | d392345dex1028.htm | EX-10.28 | 180039 |
35 | NYU-REGULUS LICENSE AGREEMENT | d392345dex1029.htm | EX-10.29 | 81666 |
36 | EXCLUSIVE PATENT LICENSE AGREEMENT | d392345dex1030.htm | EX-10.30 | 170733 |
37 | AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT | d392345dex1031.htm | EX-10.31 | 534952 |
38 | NON-EXCLUSIVE TECHNOLOGY ALLIANCE AND OPTION AGREEMENT | d392345dex1032.htm | EX-10.32 | 201277 |
39 | AMENDED AND RESTATED CONVERTIBLE PROMISSORY NOTE NO. 1 | d392345dex1033.htm | EX-10.33 | 40464 |
40 | AMENDED AND RESTATED CONVERTIBLE PROMISSORY NOTE NO. 2 | d392345dex1034.htm | EX-10.34 | 96935 |
41 | AMENDMENT #4 TO THE PRODUCT DEVELOPMENT AND COMMERCIALIZATION AGREEMENT | d392345dex1035.htm | EX-10.35 | 12660 |
42 | AMENDMENT NUMBER THREE TO THE FOUNDING INVESTOR RIGHTS AGREEMENT | d392345dex1036.htm | EX-10.36 | 11481 |
43 | COLLABORATION AND LICENSE AGREEMENT | d392345dex1037.htm | EX-10.37 | 463538 |
44 | COMMON STOCK PURCHASE AGREEMENT | d392345dex1038.htm | EX-10.38 | 188265 |
45 | COLLABORATION AND LICENSE AGREEMENT | d392345dex1039.htm | EX-10.39 | 228604 |
46 | NOTE PURCHASE AGREEMENT | d392345dex1040.htm | EX-10.40 | 64264 |
47 | CONVERTIBLE PROMISSORY NOTE | d392345dex1041.htm | EX-10.41 | 22548 |
48 | CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM | d392345dex231.htm | EX-23.1 | 1599 |
49 | CONFIDENTIAL DRAFT REGISTRATION STATEMENT #1 | d392345dex991.htm | EX-99.1 | 7233198 |
50 | CONFIDENTIAL DRAFT REGISTRATION STATEMENT #2 | d392345dex992.htm | EX-99.2 | 3187197 |
52 | GRAPHIC | g367508g04c54.jpg | GRAPHIC | 5865 |
53 | GRAPHIC | g367508g13u21.jpg | GRAPHIC | 19381 |
54 | GRAPHIC | g367508g22y52.jpg | GRAPHIC | 51984 |
55 | GRAPHIC | g367508g23x17.jpg | GRAPHIC | 50746 |
56 | GRAPHIC | g367508g26y41.jpg | GRAPHIC | 263010 |
57 | GRAPHIC | g367508g42a76.jpg | GRAPHIC | 1982 |
58 | GRAPHIC | g367508g71o46.jpg | GRAPHIC | 221857 |
59 | GRAPHIC | g367508g71t14.jpg | GRAPHIC | 16705 |
60 | GRAPHIC | g383967g13u21.jpg | GRAPHIC | 19381 |
61 | GRAPHIC | g383967g22y52.jpg | GRAPHIC | 51984 |
62 | GRAPHIC | g383967g23x17.jpg | GRAPHIC | 50746 |
63 | GRAPHIC | g383967g71t14.jpg | GRAPHIC | 16705 |
64 | GRAPHIC | g392345g13u21.jpg | GRAPHIC | 19381 |
65 | GRAPHIC | g392345g22y52.jpg | GRAPHIC | 51984 |
66 | GRAPHIC | g392345g23x17.jpg | GRAPHIC | 50746 |
67 | GRAPHIC | g392345g71t14.jpg | GRAPHIC | 16705 |
68 | GRAPHIC | g392345g81j44.jpg | GRAPHIC | 303293 |
69 | GRAPHIC | g392345g84q51.jpg | GRAPHIC | 155871 |
Complete submission text file | 0001193125-12-360813.txt | 22140456 |
IRS No.: 264738379 | State of Incorp.: DE | Fiscal Year End: 1231
Type: S-1 | Act: 33 | File No.: 333-183384 | Film No.: 121043015
SIC: 2834 Pharmaceutical Preparations