<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001504747</cik>
        <entityName>Swisher Hygiene Inc.</entityName>
        <issuerAddress>
            <street1>4725 PIEDMONT ROW DRIVE</street1>
            <street2>SUITE 400</street2>
            <city>CHARLOTTE</city>
            <stateOrCountry>NC</stateOrCountry>
            <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
            <zipCode>28210</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>704 364 7707</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Yogen Fruz World-Wide Inc.</previousName>
            <previousName>Coolbrands International Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>HARRY</firstName>
                <middleName>WAYNE</middleName>
                <lastName>HUIZENGA</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>450 E. LAS OLAS BLVD.</street1>
                <street2>SUITE 1500</street2>
                <city>FORT LAUDERDALE</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>STEVEN</firstName>
                <middleName>RICHARD</middleName>
                <lastName>BERRARD</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4725 PIEDMONT ROW DRIVE</street1>
                <street2>SUITE 400</street2>
                <city>CHARLOTTE</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>28210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DAVID</firstName>
                <middleName>OSBORN</middleName>
                <lastName>BRALEY</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4725 PIEDMONT ROW DRIVE</street1>
                <street2>SUITE 400</street2>
                <city>CHARLOTTE</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>28210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>JOHN</firstName>
                <middleName>ELLIS</middleName>
                <lastName>BUSH</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4725 PIEDMONT ROW DRIVE</street1>
                <street2>SUITE 400</street2>
                <city>CHARLOTTE</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>28210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>HARRIS</firstName>
                <middleName>W.</middleName>
                <lastName>HUDSON</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4725 PIEDMONT ROW DRIVE</street1>
                <street2>SUITE 400</street2>
                <city>CHARLOTTE</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>28210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DAVID</firstName>
                <lastName>PRUSSKY</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4725 PIEDMONT ROW DRIVE</street1>
                <street2>SUITE 400</street2>
                <city>CHARLOTTE</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>28210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>WILLIAM</firstName>
                <middleName>D.</middleName>
                <lastName>PRUITT</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4725 PIEDMONT ROW DRIVE</street1>
                <street2>SUITE 400</street2>
                <city>CHARLOTTE</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>28210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>MICHAEL</firstName>
                <lastName>SERRUYA</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4725 PIEDMONT ROW DRIVE</street1>
                <street2>SUITE 400</street2>
                <city>CHARLOTTE</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>28210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>THOMAS</firstName>
                <middleName>EDWARD</middleName>
                <lastName>AUCAMP</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4725 PIEDMONT ROW DRIVE</street1>
                <street2>SUITE 400</street2>
                <city>CHARLOTTE</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>28210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>HUGH</firstName>
                <middleName>HARLAN</middleName>
                <lastName>COOPER</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4725 PIEDMONT ROW DRIVE</street1>
                <street2>SUITE 400</street2>
                <city>CHARLOTTE</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>28210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>THOMAS</firstName>
                <middleName>CLYDE</middleName>
                <lastName>BYRNE</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4725 PIEDMONT ROW DRIVE</street1>
                <street2>SUITE 400</street2>
                <city>CHARLOTTE</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>28210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>GEORGE</firstName>
                <middleName>A.</middleName>
                <lastName>VILLASANA</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4725 PIEDMONT ROW DRIVE</street1>
                <street2>SUITE 400</street2>
                <city>CHARLOTTE</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>28210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$25,000,001 - $100,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2011-02-08</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>true</isBusinessCombinationTransaction>
            <clarificationOfResponse>A promissory note convertible into common stock was issued in the acquisition of IPABE, Inc. (d/b/a as Total Services) by the issuer.</clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>0</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
            <clarificationOfResponse>On February 8, 2011, in connection with the acquisition of IPABE, Inc., Swisher issued a note to IPABE, Inc. convertible for up to 107,143 shares of Swisher. The issuance was exempt by Section 4(2) of the Securities Act.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>In connection with the acquisition of IPABE, Inc., Swisher Hygiene issued a promissory note to IPABE, Inc., which is convertible into shares of Swisher Hygiene common stock. There were no gross proceeds from the issuance.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Swisher Hygiene Inc.</issuerName>
                <signatureName>Thomas E. Aucamp</signatureName>
                <nameOfSigner>By: Thomas E. Aucamp</nameOfSigner>
                <signatureTitle>Executive Vice President and Secretary</signatureTitle>
                <signatureDate>2011-03-21</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
