X0306 4 2020-09-18 0001634379 Metacrine, Inc. MTCR 0001504130 venBio Global Strategic Fund, L.P. 1700 OWENS STREET, SUITE 595 SAN FRANCISCO CA 94158 true true See Remarks 0001770834 venBio Global Strategic GP, L.P. 1700 OWENS STREET, SUITE 595 SAN FRANCISCO CA 94158 true true See Remarks 0001770835 venBio Global Strategic GP, Ltd. 1700 OWENS STREET, SUITE 595 SAN FRANCISCO CA 94158 true true See Remarks 0001278411 GOODMAN COREY S 1700 OWENS STREET SUITE 595 SAN FRANCISCO CA 94158 true true See Remarks Common Stock 2020-09-18 4 P 0 230000 13 A 230000 D Common Stock 2020-09-18 4 C 0 2829123 A 3059123 D Series A Convertible Preferred Stock 2020-09-18 4 C 0 1960784 0 D Common Stock 1960784 0 D Series B Convertible Preferred Stock 2020-09-18 4 C 0 472250 0 D Common Stock 472250 0 D Series C Convertible Preferred Stock 2020-09-18 4 C 0 396089 0 D Common Stock 396089 0 D Every 5.1 shares of Series A Convertible Preferred Stock, Series B Convertible Preferred Stock and Series C Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into one share Common Stock upon the closing of the Issuer's initial public offering. Share numbers give effect to such conversion. The Preferred Stock had no expiration date. The shares are held by venBio Global Strategic Fund, L.P. venBio Global Strategic GP, L.P. is the general partner of venBio Global Strategic Fund, L.P. and venBio Global Strategic GP, Ltd. is the general partner of venBio Global Strategic GP, L.P. Corey Goodman is a director of venBio Global Strategic GP, Ltd. Each of venBio Global Strategic GP, L.P., venBio Global Strategic GP, Ltd. and Mr. Goodman disclaims beneficial ownership of such securities, except to the extent of its/his indirect pecuniary interest therein. This Form 4 is being filed in conjunction with the Form 4 filed simultaneously by Robert Adelman, who serves on the Issuer's board of directors. Each of the reporting persons may be deemed directors of the Issuer by deputization of Dr. Adelman. venBio Global Strategic Fund, L.P., by: venBio Global Strategic GP, L.P., its general partner, by: venBio Global Strategic GP, Ltd., its general partner, by: /s/ David Pezeshki, as attorney-in-fact 2020-09-22 venBio Global Strategic GP , L.P., by: venBio Global Strategic GP, Ltd., its general partner, by: /s/ David Pezeshki as attorney-in-fact 2020-09-22 venBio Global Strategic GP, Ltd., by: /s/ David Pezeshki, as attorney-in-fact 2020-09-22 Corey Goodman, by: /s/ David Pezeshki, as attorney-in-fact 2020-09-22