SCHEDULE 13G/A 0001493152-24-021156 0001586446 XXXXXXXX LIVE 1 Common Stock, $0.0001 par value 10/14/2025 0001503802 Karyopharm Therapeutics Inc. 48576U205 85 Wells Avenue 2nd Floor Newton MA 02459 Rule 13d-1(c) J. Wood Capital Advisors LLC CA 0.00 1000708.00 0.00 1000708.00 1000708.00 N 4.99 OO Limited Liability Company Jason Wood X1 0.00 1000708.00 0.00 1000708.00 1000708.00 N 4.99 IN Karyopharm Therapeutics Inc. 85 Wells Avenue, 2nd Floor, Newton, Massachusetts, 02459 Each of the following is hereinafter individually referred to as a "Reporting Person" and collectively as the "Reporting Persons." This statement is filed on behalf of: J. Wood Capital Advisors LLC Jason Wood The principal business address of each of the Reporting Persons is 1820 Calistoga Road, Santa Rosa, CA 95404. J. Wood Capital Advisors LLC is organized under the laws of the State of California. Jason Wood is a citizen of the United States. Y The ownership information presented below represents beneficial ownership of the shares of Common Stock, based upon 15,926,939 shares of Common Stock outstanding as of October 14, 2025, as disclosed in the Issuer's Current Report on Form 8-K filed with the Securities and Exchange Commission on October 14, 2025. The share amounts reported herein reflect a 1-for-15 reverse stock split of the Common Stock effected by the Issuer on February 24, 2025. J. Wood Capital Advisors LLC is the record holder of 784,802 shares of Common Stock and 215,906 warrants to purchase an equal number of shares of Common Stock. The warrants contain a provision preventing exercise if such exercise would result in the Reporting Persons beneficially owning greater than 4.99% of the outstanding Common Stock when aggregated with all other shares of Common Stock beneficially owned. As a result, at any given time, the Reporting Persons may be deemed to beneficially own shares of Common Stock underlying the warrants only to the extent their total beneficial ownership does not exceed 4.99%. Jason Wood is the managing member of J. Wood Capital Advisors LLC. As a result, Jason Wood may be deemed to share beneficial ownership of the shares of Common Stock directly held by J. Wood Capital Advisors LLC. 4.99% 0 1,000,708 0 1,000,708 N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99: Joint Filing Agreement (previously filed). J. Wood Capital Advisors LLC /s/ Jason Wood 11/03/2025 Jason Wood /s/ Jason Wood 11/03/2025