X0306 4 2022-05-04 0 0001503802 Karyopharm Therapeutics Inc. KPTI 0001804460 Paulson Richard A. C/O KARYOPHARM THERAPEUTICS INC. 85 WELLS AVENUE NEWTON MA 02459 1 1 0 0 President and CEO Common Stock 2022-05-04 4 S 0 633 6.2614 D 661317 D Common Stock 2022-05-04 4 S 0 27869 6.2272 D 633448 D This transaction was a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units and does not represent a discretionary trade by the reporting person. /s/ Nancy Smith as Attorney-in-Fact for Richard Paulson 2022-05-05