X0306 4 2021-02-05 0 0001503802 Karyopharm Therapeutics Inc. KPTI 0001588438 Shacham Sharon C/O KARYOPHARM THERAPEUTICS INC. 85 WELLS AVENUE NEWTON MA 02459 0 1 0 0 President & CSO Common Stock 2021-02-05 4 M 0 14300 A 770789 D Common Stock 2021-02-05 4 M 0 14300 A 569422 I By Spouse Restricted Stock Units 2021-02-05 4 M 0 14300 0.00 D Common Stock 14300 42900 D Restricted Stock Units 2021-02-05 4 M 0 14300 0.00 D Common Stock 14300 42900 I By Spouse Restricted stock units convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis. On February 5, 2020, the reporting person was granted 57,200 restricted stock units, vesting in four equal annual installments beginning on the first anniversary of the grant date. 25% of the restricted stock units vested on February 5, 2021. Vested shares will be delivered to the reporting person as soon as practicable following the vesting date, but in any event within 30 days of such date. On February 5, 2020, the spouse of the reporting person was granted 57,200 restricted stock units, vesting in four equal annual installments beginning on the first anniversary of the grant date. 25% of the restricted stock units vested on February 5, 2021. Vested shares will be delivered to the reporting person as soon as practicable following the vesting date, but in any event within 30 days of such date. /s/ Nancy Smith as Attorney-in-Fact for Sharon Shacham 2021-02-09