X0306 4 2020-07-11 0 0001503802 Karyopharm Therapeutics Inc. KPTI 0001782186 Shah Jatin C/O KARYOPHARM THERAPEUTICS INC. 85 WELLS AVE. NEWTON MA 02459 0 1 0 0 EVP, Chief Medical Officer Common Stock 2020-07-11 4 M 0 2413 A 43172 D Common Stock 2020-07-15 4 S 0 589 19.46 D 43229 D Restricted Stock Units 2020-07-11 4 M 0 2413 0.00 D Common Stock 2413 7237 D Restricted stock units convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis. This transaction was a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units and does not represent a discretionary trade by the reporting person. Includes 646 shares acquired by the reporting person under the Karyopharm Therapeutics Inc. 2013 Employee Stock Purchase Plan on October 31, 2020. On July 11, 2019, the reporting person was granted 9,650 restricted stock units, vesting in four equal annual installments beginning on the first anniversary of the grant date. 25% of the restricted stock units vested on July 11, 2020. Vested shares will be delivered to the reporting person as soon as practicable following the vesting date, but in any event within 30 days of such date. /s/Christopher B. Primiano, Attorney-in-Fact for Jatin Shah 2020-11-04