X0306 4 2019-02-15 0 0001503802 Karyopharm Therapeutics Inc. KPTI 0001650456 Varadan Anand C/O KARYOPHARM THERAPEUTICS INC. 85 WELLS AVENUE NEWTON MA 02459 0 1 0 0 EVP, Chief Commercial Officer Stock Option (right to buy) 9.21 2019-02-15 4 A 0 102800 0.00 A 2029-02-14 Common Stock 102800 102800 D Restricted Stock Units 2019-02-15 4 A 0 38700 0.00 A Common Stock 38700 38700 D This option was granted on February 15, 2019. The shares underlying this option vest as to 25% of the shares on February 15, 2020, with the remaining 75% vesting in 36 equal monthly installments thereafter. Each restricted stock unit represents a contingent right to receive one share of Karyopharm Therapeutics Inc. common stock. The restricted stock units vest in four equal annual installments beginning February 15, 2020, the first anniversary of the grant date. Vested shares will be delivered to the reporting person as soon as practicable following each vesting date, but in any event within 30 days of such date. /s/ Christopher B. Primiano as Attorney-in-Fact for Anand Varadan 2019-02-19