X0306 4 2015-11-05 0 0001503802 Karyopharm Therapeutics Inc. KPTI 0001466562 Renz Justin A C/O KARYOPHARM THERAPEUTICS INC. 85 WELLS AVENUE NEWTON MA 02459 0 1 0 0 EVP, CFO & Treasurer Restricted Stock Units 2015-11-05 4 A 0 30000 0.00 A Common Stock 30000 30000 D Each restricted stock unit represents a contingent right to receive one share of Karyopharm Therapeutics Inc. common stock. 50% of the restricted stock units will vest on November 5, 2016, and the remaining 50% of the restricted stock units will vest on November 5, 2017. Vested shares will be delivered to the reporting person as soon as practicable following each vesting date, but in any event within 30 days of such date. /s/ Christopher B. Primiano as Attorney-in-Fact for Justin Renz 2015-11-09