<SEC-DOCUMENT>0001193125-18-251663-index.html : 20180817
<SEC-HEADER>0001193125-18-251663.hdr.sgml : 20180817
<ACCEPTANCE-DATETIME>20180817160548
ACCESSION NUMBER:		0001193125-18-251663
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20180817
DATE AS OF CHANGE:		20180817

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Karyopharm Therapeutics Inc.
		CENTRAL INDEX KEY:			0001503802
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				263931704
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-226038
		FILM NUMBER:		181025824

	BUSINESS ADDRESS:	
		STREET 1:		85 WELLS AVENUE
		STREET 2:		SECOND FLOOR
		CITY:			NEWTON
		STATE:			MA
		ZIP:			02459
		BUSINESS PHONE:		617-658-0600

	MAIL ADDRESS:	
		STREET 1:		85 WELLS AVENUE
		STREET 2:		SECOND FLOOR
		CITY:			NEWTON
		STATE:			MA
		ZIP:			02459
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>d602136d424b5.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: d602136d424b5.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g602136g59a16.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g602136g59a16.jpg

</DOCUMENT>
</SEC-DOCUMENT>