0001104659-13-080012.txt : 20131212 0001104659-13-080012.hdr.sgml : 20131212 20131101150022 ACCESSION NUMBER: 0001104659-13-080012 CONFORMED SUBMISSION TYPE: CORRESP PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20131101 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Karyopharm Therapeutics Inc. CENTRAL INDEX KEY: 0001503802 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 263931704 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: CORRESP BUSINESS ADDRESS: STREET 1: 2 MERCER ROAD CITY: NATICK STATE: MA ZIP: 01760 BUSINESS PHONE: 508-975-4820 MAIL ADDRESS: STREET 1: 2 MERCER ROAD CITY: NATICK STATE: MA ZIP: 01760 CORRESP 1 filename1.htm

 

November 1, 2013

 

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C.  20549

 

Re:                             Karyopharm Therapeutics Inc.

Registration Statement on Form S-1 (SEC File No. 333-191584)

 

Ladies and Gentlemen:

 

In connection with the above-referenced Registration Statement, and pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), we hereby join in the request of Karyopharm Therapeutics Inc. that the effective date of the Registration Statement be accelerated so that it will be declared effective at 4:00 p.m., New York City time, on November 5, 2013 or as soon thereafter as practicable.

 

Pursuant to Rule 460 under the Act, we wish to advise you that we have distributed approximately 2,133 copies of the Preliminary Prospectus dated October 28, 2013 (the “Preliminary Prospectus”) through the date hereof, to underwriters, dealers, institutions and others.

 

In connection with the Preliminary Prospectus distribution for the above-reference issue, the prospective underwriters have confirmed that they are complying with the 48-hour requirement as promulgated by Rule 15c2-8 under the Securities Exchange Act of 1934, as amended.

 

[Remainder of page intentionally left blank]

 


 

Very truly yours,

 

 

 

 

MERRILL LYNCH, PIERCE, FENNER & SMITH

 

INCORPORATED

 

LEERINK SWANN LLC

 

 

 

 

 

 

By:

MERRILL LYNCH, PIERCE, FENNER & SMITH

 

 

INCORPORATED

 

 

 

 

 

 

 

 

 

By:

/s/ Michele A. H. Allong

 

 

Name:

Michele A. H. Allong

 

 

Title:

Authorized Signatory

 

 

For themselves and as Representatives of the other Underwriters.

 

[Signature Page to Karyopharm Therapeutics Inc. S-1 Acceleration Request]