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Income Taxes - Schedule of Reconciliation of Income Tax Expense Computed at Statutory Federal Income Tax Rate to Income Taxes (Detail)
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Effective Income Tax Rate Reconciliation, Percent [Abstract]      
Federal income tax expense at statutory rate 21.00% 21.00% 21.00%
State income tax, net of federal benefit 4.00% 4.00% 0.80%
Permanent differences (1.00%) (3.30%) (2.70%)
Research and development credit 7.30% 6.30% 11.30%
Foreign rate differential 0.00% 0.00% (5.20%)
Change in valuation allowance (22.90%) (29.30%) (35.40%)
Migrated Intellectual Property 0.00% 0.00% 13.90%
Stock-based compensation and 162m adjustment (5.00%) (2.00%) (4.30%)
Provision to return adjustments (2.80%) 0.00% (0.50%)
Other (0.80%) 3.10% 0.90%
Effective income tax rate (0.20%) (0.20%) (0.20%)