Income Taxes - Schedule of Significant Components of Company's Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Deferred Tax Assets, Net [Abstract]
U.S. and state net operating loss carryforwards	$ 198,158	$ 189,629
Research and development credits	108,682	100,436
Fixed assets and intangible assets	25,028	27,312
Stock-based compensation	8,500	13,818
Accruals and other temporary differences	6,380	6,613
Interest Expense - Sec 163(j)	6,894	9,236
Lease liability	1,461	2,193
Deferred royalty obligation	8,310	1,805
Capitalized research and development	47,986	27,748
Deferred royalty embedded derivative	671	679
Unicap - Sec 263A	800	1,214
Valuation allowance	(411,838)	(379,166)
Total deferred tax assets	1,032	1,517
Deferred Tax Liabilities, Gross [Abstract]
Convertible debt amortization	(7)	(5)
Right-of-use asset	(1,025)	1,512
Total deferred tax liabilities	(1,032)	(1,517)
Net deferred tax assets	$ 0	$ 0