Stock-based Compensation - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands		12 Months Ended
	May 19, 2022	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021	May 24, 2023	Feb. 28, 2023	May 31, 2022	Feb. 28, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense		$ 21,709	$ 35,399	$ 29,783
Total stock-based compensation expense		$ 21,709	35,399	29,783
Employee And Non Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total intrinsic value of stock options exercised | $			$ 300	$ 1,000
Weighted-average grant date fair values of options granted (in dollars per share) | $ / shares		$ 1.54	$ 5.83	$ 7.57
Period for recognition of unrecognized expense		1 year 8 months 12 days
Total unrecognized stock-based compensation expense related to unvested stock options including estimated forfeitures | $		$ 9,700
Restricted Stock Units (RSUs) [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense		$ 10,662	$ 12,587	$ 9,348
Restricted Stock Units (RSU) and Performance Based Restricted Stock Units (PSU) [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Period for recognition of unrecognized expense		1 year 10 months 24 days
Total unrecognized stock-based compensation expense related to unvested stock options including estimated forfeitures | $		$ 24,000
Number of Shares Underlying RSUs, Granted		7,075,522
Maximum [Member] | Employee And Non Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total intrinsic value of stock options exercised | $		$ 100
Former Chief Executive Officer and Former Chief Scientific Officer
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense			7,400
2010 Plan [Member] | Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares reserved for issuance (in shares)		484,848
2022 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for future grants		8,591,362
Number of additional shares available under the 2013 plan	5,000,000
2022 Plan [Member] | Restricted Stock Units (RSUs) [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting rights, percentage	25.00%
ESPP [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares of common stock authorized		242,424
Period for recognition of unrecognized expense		4 months
Offering period		6 months
Purchase price of common stock		85.00%
Number of shares reserved for issuance (in shares)		1,632,818
Percentage of shares of common stock available for issuance		1.00%
Total unrecognized stock-based compensation expense		$ 200
Employee stock purchase plan, description		In 2013, our stockholders approved an increase in the number of shares of common stock authorized for issuance pursuant to the ESPP to 242,424 shares of common stock, plus an annual increase to be added on the first day of each fiscal year, commencing on January 1, 2015 and ending on December 31, 2023, equal to the lesser of 484,848 shares of our common stock, 1% of the number of outstanding shares on such date, or an amount determined by the Board (the "Evergreen Provision").
Employee stock purchase plan, amount withheld from employees | $		$ 1,100	$ 2,300	$ 2,000
Common stock available for payment related to tax withholding		638,182	508,391	330,257
ESPP [Member] | Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares of common stock authorized					4,008,923
ESPP [Member] | Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares of common stock authorized					2,508,923
2022 Stock Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares of common stock authorized		25,753,096				1,200,000	850,000
Shares available for future grants		874,498
Number of shares reserved for issuance (in shares)								850,000