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Cover Page - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2023
Feb. 23, 2024
Jun. 30, 2023
Cover [Abstract]      
Document Type 10-K    
Amendment Flag false    
Document Period End Date Dec. 31, 2023    
Document Fiscal Year Focus 2023    
Document Fiscal Period Focus FY    
Current Fiscal Year End Date --12-31    
Entity Registrant Name KARYOPHARM THERAPEUTICS INC.    
Trading Symbol KPTI    
Entity Central Index Key 0001503802    
Entity Filer Category Accelerated Filer    
Entity Small Business false    
Entity Emerging Growth Company false    
Entity Common Stock, Shares Outstanding   115,067,083  
Entity Public Float     $ 201.1
Entity Well-known Seasoned Issuer No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity File Number 001-36167    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 26-3931704    
Entity Address, Address Line One 85 Wells Avenue, 2nd Floor    
Entity Address, City or Town Newton    
Entity Address, Postal Zip Code 02459    
City Area Code 617    
Local Phone Number 658-0600    
Document Transition Report false    
Document Annual Report true    
Entity Shell Company false    
Document Financial Statement Error Correction [Flag] false    
Entity Voluntary Filers No    
Entity Address, State or Province MA    
Title of 12(b) Security Common Stock    
Security Exchange Name NASDAQ    
ICFR Auditor Attestation Flag true    
Auditor Name Ernst & Young LLP    
Auditor Location Boston, Massachusetts    
Auditor Firm ID 42    
Documents Incorporated by Reference

Portions of the registrant’s Proxy Statement for its 2024 Annual Meeting of Stockholders, which the registrant intends to file with the Securities and Exchange Commission no later than 120 days after the registrant’s fiscal year end of December 31, 2023, are incorporated by reference into Part III of this Annual Report on Form 10-K.