X0508 4 2023-09-05 0001503802 Karyopharm Therapeutics Inc. KPTI 0001804460 Paulson Richard A. C/O KARYOPHARM THERAPEUTICS INC. 85 WWELLS AVENUE NEWTON MA 02459 true true false false President and CEO false Common Stock 2023-09-05 4 S false 3558 1.33 D 798460 D Common Stock 2023-09-05 4 S false 64 1.32 D 798396 D This transaction was effected pursuant to a durable automatic sale instruction plan adopted by the reporting person on June 10, 2021, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units. The sale does not represent a discretionary trade by the reporting person. /s/ Nancy Smith as Attorney-in-Fact for Richard Paulson 2023-09-06