Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Operating activities
Net loss	$ (66,756)	$ (90,461)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	11,449	22,429
Depreciation and amortization	373	326
Amortization of debt issuance costs	392	400
Net amortization of premiums and discounts on investments	(2,141)	(71)
Other	3	(4)
Changes in operating assets and liabilities:
Accounts receivable, net	14,806	(982)
Inventory	552	636
Prepaid expenses and other assets	1,724	(14,860)
Operating lease right-of-use assets	942	808
Accounts payable	(486)	91
Accrued expenses and other liabilities	(4,081)	(11,567)
Operating lease liabilities	(1,385)	(1,086)
Net cash used in operating activities	(44,608)	(94,341)
Investing activities
Purchases of property and equipment	0	(79)
Proceeds from sales and maturities of investments	85,308	48,468
Purchases of investments	(96,526)	(99,020)
Net cash used in investing activities	(11,218)	(50,631)
Financing activities
Proceeds from issuance of common stock, net of issuance costs	0	29,294
Proceeds from the exercise of stock options and shares issued under employee stock purchase plan	860	2,802
Net cash provided by financing activities	860	32,096
Effect of exchange rate on cash, cash equivalents and restricted cash	(71)	(544)
Net decrease in cash, cash equivalents and restricted cash	(55,037)	(113,420)
Cash, cash equivalents and restricted cash at beginning of period	136,885	197,445
Cash, cash equivalents and restricted cash at end of period	81,848	84,025
Reconciliation of cash, cash equivalents and restricted cash reported within the consolidated balance sheets
Cash and cash equivalents	80,894	82,248
Short-term restricted cash	567	1,146
Long-term restricted cash	387	631
Total cash, cash equivalents and restricted cash	81,848	84,025
Supplemental disclosures:
Cash paid for interest on convertible debt	2,588	2,588
Cash paid for amounts included in the measurement of operating lease liabilities	1,847	1,682
Cash paid for interest on deferred royalty obligation	$ 8,192	$ 20,746