Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenues:
Revenue from contract with customer, license and other revenue	$ 37,579	$ 39,679	$ 76,277	$ 87,349
Operating expenses:
Research and development	31,477	44,309	63,816	86,371
Selling, general and administrative	34,481	37,339	70,388	76,107
Total operating expenses	67,152	82,587	136,749	164,843
Loss from operations	(29,573)	(42,908)	(60,472)	(77,494)
Other income (expense):
Interest income	2,824	293	5,673	367
Interest expense	(5,784)	(6,313)	(11,542)	(12,997)
Other income (expense), net	30	(13)	(234)	(86)
Total other expense, net	(2,930)	(6,033)	(6,103)	(12,716)
Loss before income taxes	(32,503)	(48,941)	(66,575)	(90,210)
Income tax provision	(127)	(121)	(181)	(251)
Net loss	$ (32,630)	$ (49,062)	$ (66,756)	$ (90,461)
Net loss per share-basic	$ (0.29)	$ (0.62)	$ (0.59)	$ (1.15)
Net loss per share-diluted	$ (0.29)	$ (0.62)	$ (0.59)	$ (1.15)
Weighted-average number of common shares outstanding used to compute net loss per share-basic	114,207,000	79,651,000	113,846,000	78,616,000
Weighted-average number of common shares outstanding used to compute net loss per share-diluted	114,207,000	79,651,000	113,846,000	78,616,000
Product [Member]
Revenues:
Revenue from contract with customer, license and other revenue	$ 28,460	$ 29,010	$ 56,748	$ 57,310
Operating expenses:
Cost of sales	1,194	939	2,545	2,365
License and Other [Member]
Revenues:
Revenue from contract with customer, license and other revenue	$ 9,119	$ 10,669	$ 19,529	$ 30,039