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Pay vs Performance Disclosure - USD ($)
 4 Months Ended 12 Months Ended 20 Months Ended
May 03, 2021
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2022
Pay vs Performance Disclosure [Table]          
Pay vs Performance [Table Text Block]  

Pay Versus Performance

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Value of Initial Fixed $100 Investment Based On:

 

 

 

 

 

 

 

Year

 

 

Summary
Compensation
Table Total
for First PEO
(1)($)

 

 

Summary
Compensation
Table Total
for Second PEO
(1)($)

 

 

Compensation
Actually Paid
to First PEO
(2)($)

 

 

Compensation
Actually
Paid to
Second PEO
(2)($)

 

 

Average
Summary
Compensation
Table Total
for Non-PEO
Named
Executive
Officers
(1)($)

 

 

Average
Compensation
Actually Paid
to Non-PEO
Named
Executive
Officers
(2)($)

 

 

Total
Shareholder
Return
($)

 

 

Peer Group
Total
Shareholder
Return
(3)($)

 

 

Net
Income
($)

 

 

Company
Selected
Measure:
Net Product
Revenue
($)

 

 

2022

 

 

N/A

 

 

 

6,910,015

 

 

N/A

 

 

 

1,559,966

 

 

 

2,891,674

 

 

 

1,670,016

 

 

 

17.74

 

 

 

113.65

 

 

 

(165,291,065

)

 

 

120,444,930

 

 

2021

 

 

 

3,069,589

 

 

 

8,355,172

 

 

 

(1,074,531

)

 

 

5,402,741

 

 

 

2,004,146

 

 

 

(305,039

)

 

 

33.54

 

 

 

126.45

 

 

 

(124,087,976

)

 

 

98,435,969

 

 

2020

 

 

 

3,937,039

 

 

N/A

 

 

 

1,793,017

 

 

N/A

 

 

 

2,968,850

 

 

 

1,460,323

 

 

 

80.75

 

 

 

126.42

 

 

 

(196,273,469

)

 

 

76,209,631

 
(1)
For 2022, our PEO was Mr. Paulson who was appointed as our President and Chief Executive Officer effective May 2, 2021 (“Second PEO”), and our Other NEOs were Mr. Mason, Ms. Cheng, Mr. Mano, Mr. Poulton, Mr. Frenkel, our former Chief Development Officer, and Dr. Shacham, our former President and Chief Scientific Officer. For 2021, our PEOs were Dr. Kauffman, who served as our Chief Executive Officer until May 3, 2021 (“First PEO”), and Mr. Paulson, and our Other NEOs were Mr. Mason, Mr. Frenkel, Dr. Shacham, and Dr. Shah, our former Chief Medical Officer. For 2020, our PEO was Dr. Kauffman and our Other NEOs were Mr. Mason and Dr. Shacham.
(2)
The following table describes the adjustments, each of which is prescribed by SEC rules, to calculate the CAP Amounts from the SCT Amounts. The SCT Amounts and the CAP Amounts do not reflect the actual amount of compensation earned by or paid to our executives during the applicable years, but rather are amounts determined in accordance with Item 402 of Regulation S-K under the Exchange Act. No awards vested in the year they were granted.

 

 

 

 

2022 ($)

 

 

2021 ($)

 

 

2020 ($)

 

Adjustments

 

 

First
PEO

 

 

Second PEO

 

 

Other NEOs*

 

 

First
PEO

 

 

Second PEO

 

 

Other
NEOs*

 

 

First
 PEO

 

 

Second PEO

 

 

Other NEOs*

 

Total Compensation from SCT(1)

 

 

—

 

 

 

6,910,015

 

 

 

2,891,674

 

 

 

3,069,589

 

 

 

8,355,172

 

 

 

2,004,146

 

 

 

3,937,039

 

 

 

—

 

 

 

2,968,850

 

Adjustments for defined benefit and actuarial pension plans: Not applicable

 

Adjustments for stock and option awards

 

(Subtract): Aggregate value for stock awards and option awards included in SCT for the covered fiscal year

 

 

—

 

 

 

(5,545,772

)

 

 

(2,095,082

)

 

 

(2,340,049

)

 

 

(7,086,583

)

 

 

(1,302,726

)

 

 

(2,950,785

)

 

 

—

 

 

 

(2,316,987

)

Add: Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end

 

 

—

 

 

 

1,611,947

 

 

 

511,965

 

 

 

847,392

 

 

 

4,468,563

 

 

 

481,405

 

 

 

2,377,252

 

 

 

—

 

 

 

1,866,622

 

Add (Subtract): Change as of the end of the covered fiscal year (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end

 

 

—

 

 

 

(1,339,720

)

 

 

(111,302

)

 

 

(1,919,745

)

 

 

(136,675

)

 

 

(1,093,312

)

 

 

(982,194

)

 

 

—

 

 

 

(653,536

)

Add (Subtract): Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year

 

 

—

 

 

 

(76,504

)

 

 

472,761

 

 

 

(731,718

)

 

 

(197,736

)

 

 

(394,552

)

 

 

(588,295

)

 

 

—

 

 

 

(404,627

)

CAP Amounts (as calculated)

 

 

—

 

 

 

1,559,966

 

 

 

1,670,016

 

 

 

(1,074,531

)

 

 

5,402,741

 

 

 

(305,039

)

 

 

1,793,017

 

 

 

—

 

 

 

1,460,323

 
     
Company Selected Measure Name   Net ProductRevenue      
Named Executive Officers, Footnote [Text Block]  
(1)
For 2022, our PEO was Mr. Paulson who was appointed as our President and Chief Executive Officer effective May 2, 2021 (“Second PEO”), and our Other NEOs were Mr. Mason, Ms. Cheng, Mr. Mano, Mr. Poulton, Mr. Frenkel, our former Chief Development Officer, and Dr. Shacham, our former President and Chief Scientific Officer. For 2021, our PEOs were Dr. Kauffman, who served as our Chief Executive Officer until May 3, 2021 (“First PEO”), and Mr. Paulson, and our Other NEOs were Mr. Mason, Mr. Frenkel, Dr. Shacham, and Dr. Shah, our former Chief Medical Officer. For 2020, our PEO was Dr. Kauffman and our Other NEOs were Mr. Mason and Dr. Shacham.
      
Adjustment To PEO Compensation, Footnote [Text Block]  
(2)
The following table describes the adjustments, each of which is prescribed by SEC rules, to calculate the CAP Amounts from the SCT Amounts. The SCT Amounts and the CAP Amounts do not reflect the actual amount of compensation earned by or paid to our executives during the applicable years, but rather are amounts determined in accordance with Item 402 of Regulation S-K under the Exchange Act. No awards vested in the year they were granted.

 

 

 

 

2022 ($)

 

 

2021 ($)

 

 

2020 ($)

 

Adjustments

 

 

First
PEO

 

 

Second PEO

 

 

Other NEOs*

 

 

First
PEO

 

 

Second PEO

 

 

Other
NEOs*

 

 

First
 PEO

 

 

Second PEO

 

 

Other NEOs*

 

Total Compensation from SCT(1)

 

 

—

 

 

 

6,910,015

 

 

 

2,891,674

 

 

 

3,069,589

 

 

 

8,355,172

 

 

 

2,004,146

 

 

 

3,937,039

 

 

 

—

 

 

 

2,968,850

 

Adjustments for defined benefit and actuarial pension plans: Not applicable

 

Adjustments for stock and option awards

 

(Subtract): Aggregate value for stock awards and option awards included in SCT for the covered fiscal year

 

 

—

 

 

 

(5,545,772

)

 

 

(2,095,082

)

 

 

(2,340,049

)

 

 

(7,086,583

)

 

 

(1,302,726

)

 

 

(2,950,785

)

 

 

—

 

 

 

(2,316,987

)

Add: Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end

 

 

—

 

 

 

1,611,947

 

 

 

511,965

 

 

 

847,392

 

 

 

4,468,563

 

 

 

481,405

 

 

 

2,377,252

 

 

 

—

 

 

 

1,866,622

 

Add (Subtract): Change as of the end of the covered fiscal year (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end

 

 

—

 

 

 

(1,339,720

)

 

 

(111,302

)

 

 

(1,919,745

)

 

 

(136,675

)

 

 

(1,093,312

)

 

 

(982,194

)

 

 

—

 

 

 

(653,536

)

Add (Subtract): Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year

 

 

—

 

 

 

(76,504

)

 

 

472,761

 

 

 

(731,718

)

 

 

(197,736

)

 

 

(394,552

)

 

 

(588,295

)

 

 

—

 

 

 

(404,627

)

CAP Amounts (as calculated)

 

 

—

 

 

 

1,559,966

 

 

 

1,670,016

 

 

 

(1,074,531

)

 

 

5,402,741

 

 

 

(305,039

)

 

 

1,793,017

 

 

 

—

 

 

 

1,460,323

 
     
Non-PEO NEO Average Total Compensation Amount   $ 2,891,674 $ 2,004,146 $ 2,968,850  
Non-PEO NEO Average Compensation Actually Paid Amount   $ 1,670,016 (305,039) 1,460,323  
Compensation Actually Paid vs. Total Shareholder Return [Text Block]  

Compensation Actually Paid vs. TSR

img94466677_3.jpg 

 

      
Compensation Actually Paid vs. Net Income [Text Block]  

Compensation Actually Paid vs. Net Income

img94466677_4.jpg 

      
Compensation Actually Paid vs. Company Selected Measure [Text Block]  

Compensation Actually Paid vs. Net Product Revenue

img94466677_5.jpg 

      
Tabular List [Table Text Block]  

The following table identifies five financial and non-financial performance measures that, in our assessment, represent the most important performance measures we used to link the CAP Amounts for our NEOs for 2022 (our most recently completed fiscal year), to company performance. Of these measures, we have identified Net Product Revenue as the most important of our financial performance measures used to link CAP Amounts for our executives for 2022 to Company performance.

 

2022 Performance Measures

Net Product Revenue

License and Other Revenue

Year-end Cash

Adherence to Budget

Clinical Trial Execution
     
Total Shareholder Return Amount   $ 17.74 33.54 80.75  
Peer Group Total Shareholder Return Amount   113.65 126.45 126.42  
Net Income (Loss)   $ (165,291,065) $ (124,087,976) $ (196,273,469)  
Company Selected Measure Amount   120,444,930 98,435,969 76,209,631  
PEO Name Dr. Kauffman     Dr. Kauffman Mr. Paulson
Measure [Axis]: 1          
Pay vs Performance Disclosure [Table]          
Measure Name   Net Product Revenue      
Measure [Axis]: 2          
Pay vs Performance Disclosure [Table]          
Measure Name   License and Other Revenue      
Measure [Axis]: 3          
Pay vs Performance Disclosure [Table]          
Measure Name   Year-end Cash      
Measure [Axis]: 4          
Pay vs Performance Disclosure [Table]          
Measure Name   Adherence to Budget      
Measure [Axis]: 5          
Pay vs Performance Disclosure [Table]          
Measure Name   Clinical Trial Execution      
Dr. Kauffman [Member]          
Pay vs Performance Disclosure [Table]          
PEO Total Compensation Amount   $ 0 $ 3,069,589 $ 3,937,039  
PEO Actually Paid Compensation Amount   0 (1,074,531) 1,793,017  
Mr. Paulson [Member]          
Pay vs Performance Disclosure [Table]          
PEO Total Compensation Amount   6,910,015 8,355,172 0  
PEO Actually Paid Compensation Amount   1,559,966 5,402,741 0  
PEO [Member] | Dr. Kauffman [Member] | Aggregate value for stock awards and option awards included in SCT for the covered fiscal year [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   0 (2,340,049) (2,950,785)  
PEO [Member] | Dr. Kauffman [Member] | Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   0 847,392 2,377,252  
PEO [Member] | Dr. Kauffman [Member] | Change as of the end of the covered fiscal year (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   0 (1,919,745) (982,194)  
PEO [Member] | Dr. Kauffman [Member] | Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   0 (731,718) (588,295)  
PEO [Member] | Mr. Paulson [Member] | Aggregate value for stock awards and option awards included in SCT for the covered fiscal year [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   (5,545,772) (7,086,583) 0  
PEO [Member] | Mr. Paulson [Member] | Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   1,611,947 4,468,563 0  
PEO [Member] | Mr. Paulson [Member] | Change as of the end of the covered fiscal year (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   (1,339,720) (136,675) 0  
PEO [Member] | Mr. Paulson [Member] | Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   (76,504) (197,736) 0  
Non-PEO NEO [Member] | Aggregate value for stock awards and option awards included in SCT for the covered fiscal year [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   (2,095,082) (1,302,726) (2,316,987)  
Non-PEO NEO [Member] | Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   511,965 481,405 1,866,622  
Non-PEO NEO [Member] | Change as of the end of the covered fiscal year (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   (111,302) (1,093,312) (653,536)  
Non-PEO NEO [Member] | Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year [Member]          
Pay vs Performance Disclosure [Table]          
Adjustment to Compensation Amount   $ 472,761 $ (394,552) $ (404,627)