Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenues:
Revenue from contract with customer, license and other revenue	$ 36,145	$ 37,689	$ 123,494	$ 83,550
Operating expenses:
Research and development	31,359	45,808	117,730	116,839
Selling, general and administrative	34,645	35,104	110,752	109,284
Total operating expenses	66,984	81,501	231,827	228,783
Loss from operations	(30,839)	(43,812)	(108,333)	(145,233)
Other income (expense):
Interest income	658	98	1,025	527
Interest expense	(6,114)	(8,010)	(19,111)	(18,106)
Other income (expense), net	16	18	(70)	393
Total other expense, net	(5,440)	(7,894)	(18,156)	(17,186)
Loss before income taxes	(36,279)	(51,706)	(126,489)	(162,419)
Income tax provision	(45)	(106)	(296)	(389)
Net loss	$ (36,324)	$ (51,812)	$ (126,785)	$ (162,808)
Net loss per share-basic	$ (0.45)	$ (0.69)	$ (1.60)	$ (2.17)
Net loss per share-diluted	$ (0.45)	$ (0.69)	$ (1.60)	$ (2.17)
Weighted-average number of common shares outstanding used to compute net loss per share-basic	80,210,000	75,461,000	79,153,000	75,065,000
Weighted-average number of common shares outstanding used to compute net loss per share-diluted	80,210,000	75,461,000	79,153,000	75,065,000
Product [Member]
Revenues:
Revenue from contract with customer, license and other revenue	$ 32,009	$ 26,723	$ 89,319	$ 68,633
Operating expenses:
Cost of sales	980	589	3,345	2,660
License and Other [Member]
Revenues:
Revenue from contract with customer, license and other revenue	$ 4,136	$ 10,966	$ 34,175	$ 14,917