Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating activities
Net loss	$ (90,461)	$ (110,996)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	326	464
Net amortization of premiums and discounts on investments	(71)	1,148
Amortization of debt issuance costs	400	386
Stock-based compensation expense	22,429	15,494
Change in fair value of embedded derivative liability	0	(610)
Other	(4)	231
Changes in operating assets and liabilities:
Accounts receivable, net	(982)	(5,006)
Inventory	636	(1,506)
Prepaid expenses and other assets	(14,860)	(5,773)
Operating lease right-of-use assets	808	698
Accounts payable	91	(2,141)
Accrued expenses and other liabilities	(11,567)	196
Deferred revenue	0	(297)
Operating lease liabilities	(1,086)	(924)
Net cash used in operating activities	(94,341)	(108,636)
Investing activities
Purchases of property and equipment	(79)	0
Proceeds from sales and maturities of investments	48,468	124,376
Purchases of investments	(99,020)	(34,732)
Net cash (used in) provided by investing activities	(50,631)	89,644
Financing activities
Proceeds from issuance of common stock, net of issuance costs	29,294	9,903
Proceeds from the exercise of stock options and shares issued under employee stock purchase plan	2,802	2,833
Proceeds from Amended Revenue Interest Agreement	0	60,000
Net cash provided by financing activities	32,096	72,736
Effect of exchange rate on cash, cash equivalents and restricted cash	(544)	(155)
Net (decrease) increase in cash, cash equivalents and restricted cash	(113,420)	53,589
Cash, cash equivalents and restricted cash at beginning of period	197,445	89,121
Cash, cash equivalents and restricted cash at end of period	84,025	142,710
Reconciliation of cash, cash equivalents and restricted cash reported within the consolidated balance sheets
Cash and cash equivalents	82,248	141,309
Short-term restricted cash	1,146	762
Long-term restricted cash	631	639
Total cash, cash equivalents and restricted cash	84,025	142,710
Supplemental disclosures:
Cash paid for interest on convertible debt	2,588	2,588
Cash paid for amounts included in the measurement of operating lease liabilities	1,682	1,630
Cash paid for interest on deferred royalty obligation	$ 20,746	$ 4,068