Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues:
Revenue from contract with customer, license and other revenue	$ 39,679	$ 22,601	$ 87,349	$ 45,861
Operating expenses:
Research and development	44,309	33,981	86,371	71,031
Selling, general and administrative	37,339	36,530	76,107	74,180
Total operating expenses	82,587	71,649	164,843	147,282
Loss from operations	(42,908)	(49,048)	(77,494)	(101,421)
Other income (expense):
Interest income	293	165	367	429
Interest expense	(6,313)	(5,001)	(12,997)	(10,096)
Other (expense) income, net	(13)	436	(86)	375
Total other expense, net	(6,033)	(4,400)	(12,716)	(9,292)
Loss before income taxes	(48,941)	(53,448)	(90,210)	(110,713)
Income tax provision	(121)	(134)	(251)	(283)
Net loss	$ (49,062)	$ (53,582)	$ (90,461)	$ (110,996)
Net loss per share-basic	$ (0.62)	$ (0.71)	$ (1.15)	$ (1.48)
Net loss per share-diluted	$ (0.62)	$ (0.71)	$ (1.15)	$ (1.48)
Weighted-average number of common shares outstanding used to compute net loss per share-basic	79,651,000	75,189,000	78,616,000	74,863,000
Weighted-average number of common shares outstanding used to compute net loss per share-diluted	79,651,000	75,189,000	78,616,000	74,863,000
Product [Member]
Revenues:
Revenue from contract with customer, license and other revenue	$ 29,010	$ 20,179	$ 57,310	$ 41,910
Operating expenses:
Cost of sales	939	1,138	2,365	2,071
License and Other [Member]
Revenues:
Revenue from contract with customer, license and other revenue	$ 10,669	$ 2,422	$ 30,039	$ 3,951