Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenues:
Total revenues	$ 47,670	$ 23,260
Operating expenses:
Cost of sales	1,426	933
Research and development	42,062	37,050
Selling, general and administrative	38,768	37,650
Total operating expenses	82,256	75,633
Loss from operations	(34,586)	(52,373)
Other income (expense):
Interest income	74	264
Interest expense	(6,684)	(5,095)
Other expense, net	(73)	(61)
Total other expense, net	(6,683)	(4,892)
Loss before income taxes	(41,269)	(57,265)
Income tax provision	(130)	(149)
Net loss	$ (41,399)	$ (57,414)
Net loss per share—basic and diluted	$ (0.53)	$ (0.77)
Weighted-average number of common shares outstanding used to compute net loss per share-basic and diluted	77,570	74,517
Product revenue
Revenues:
Total revenues	$ 28,300	$ 21,731
License and other revenue
Revenues:
Total revenues	$ 19,370	$ 1,529