Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 153,256	$ 190,459
Short-term investments	52,055	38,156
Accounts receivable, net	24,992	22,497
Inventory	3,874	4,106
Prepaid expenses	12,207	12,511
Other current assets	29,135	1,528
Restricted cash	1,014	6,349
Total current assets	276,533	275,606
Property and equipment, net	1,544	1,642
Operating lease right-of-use assets	7,518	7,915
Other assets	7,802	19,505
Restricted cash	636	637
Total assets	294,033	305,305
Current liabilities:
Accounts payable	3,440	1,603
Accrued expenses	58,371	69,121
Operating lease liabilities	2,463	2,316
Other current liabilities	2,063	678
Total current liabilities	66,337	73,718
Convertible senior notes	169,491	169,293
Deferred royalty obligation	132,998	132,998
Operating lease liabilities, net of current portion	8,286	8,969
Total liabilities	377,112	384,978
Stockholders' (deficit) equity:
Preferred stock, $0.0001 par value; 5,000 shares authorized; none issued and outstanding
Common stock, $0.0001 par value; 200,000 shares authorized; 79,419 and 75,746 shares issued and outstanding at March 31, 2022 and December 31, 2021, respectively	8	8
Additional paid-in capital	1,136,873	1,098,776
Accumulated other comprehensive income	87	191
Accumulated deficit	(1,220,047)	(1,178,648)
Total stockholders' deficit	(83,079)	(79,673)
Total liabilities and stockholders' (deficit) equity	$ 294,033	$ 305,305