<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0607</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2026-03-18</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001503584</issuerCik>
        <issuerName>Costamare Inc.</issuerName>
        <issuerTradingSymbol>CMRE</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001983417</rptOwnerCik>
            <rptOwnerName>Zikos Grigorios</rptOwnerName>
        </reportingOwnerId>
    <reportingOwnerAddress>
      <rptOwnerNonUSAddressFlag>true</rptOwnerNonUSAddressFlag>
      <rptOwnerStreet1>60 ZEPHYROU STREET &amp; SYNGROU AVENUE</rptOwnerStreet1>
      <rptOwnerCity>ATHENS</rptOwnerCity>
      <rptOwnerCountry>J3</rptOwnerCountry>
      <rptOwnerZipCode>17564</rptOwnerZipCode>
    </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>true</isOfficer>
            <officerTitle>Chief Financial Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, par value $0.0001 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>59840</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The reported shares are owned by Dilofo Holdings Ltd, an entity in which the reporting person and his spouse each own 50%. The reporting person disclaims beneficial ownership of the securities held jointly with his spouse except to the extent of his pecuniary interest therein.</footnote>
    </footnotes>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Anastasios Gabrielides, by power of attorney</signatureName>
        <signatureDate>2026-03-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
