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Net loss per share - Common share equivalents have been excluded from the calculation of diluted net loss per share (Details) - shares
3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Stock options        
Net loss per share        
Number of common share equivalents excluded in the calculation of diluted net loss per share 2,578,139 2,277,005 2,382,744 2,277,005
Unvested restricted stock and stock units        
Net loss per share        
Number of common share equivalents excluded in the calculation of diluted net loss per share 928,192 572,132 759,143 572,132