Collaboration and license arrangements (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaboration and license arrangements
Revenue	$ 110,556	$ 86,377	$ 56,734
Previously deferred revenue		1,200
Deferred revenue	500	500
Joint development and license agreement | Maximum
Collaboration and license arrangements
Revenue	100	100	100
Abbot license agreement
Collaboration and license arrangements
Initial license fee receivable	$ 10,000
Number of days notice to terminate agreement	60 days
Collaboration and license revenue
Collaboration and license arrangements
Revenue	$ 648	11,809	$ 184
Collaboration and license revenue | Abbot license agreement
Collaboration and license arrangements
Revenue	$ 0	$ 10,000