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Collaboration and license arrangements (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2020
Jun. 30, 2019
Dec. 31, 2019
Collaboration and license arrangements          
Revenue $ 13,130 $ 13,536 $ 28,857 $ 25,872  
Deferred revenue 1,700   1,700   $ 1,700
Joint development and license agreement | Maximum          
Collaboration and license arrangements          
Revenue $ 100   $ 200