The number of shares the entity is obligated to issue warrants for as of the reporting date.

No definition available.

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- Definition

Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257

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- References

No definition available.

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- Definition

Ratio applied to the conversion of stock split, for example but not limited to, one share converted to two or two shares converted to one.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section S99
-Paragraph 4
-Subparagraph (SAB TOPIC 4.C)
-URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187143-122770

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Significant accounting policies - Net loss per share (Details)		12 Months Ended
	Dec. 04, 2017	Dec. 31, 2018 shares	Dec. 31, 2017 shares	Dec. 31, 2016 shares
Outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share
Number of dilutive securities excluded in the calculation of diluted net loss per share		2,914,420	2,513,125	15,122,793
Reverse stock split ratio	0.311
Series A Preferred Stock
Outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share
Number of dilutive securities excluded in the calculation of diluted net loss per share				4,884,869
Series B Preferred Stock
Outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share
Number of dilutive securities excluded in the calculation of diluted net loss per share				1,873,561
Series C Preferred Stock
Outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share
Number of dilutive securities excluded in the calculation of diluted net loss per share				2,677,649
Series D Preferred Stock
Outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share
Number of dilutive securities excluded in the calculation of diluted net loss per share				3,864,421
Unvested restricted common stock
Outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share
Number of dilutive securities excluded in the calculation of diluted net loss per share		361,468	177,192	376,248
Outstanding stock options
Outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share
Number of dilutive securities excluded in the calculation of diluted net loss per share		2,476,911	2,249,843	1,119,671
Outstanding preferred warrants
Outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share
Number of dilutive securities excluded in the calculation of diluted net loss per share				326,374
Outstanding warrants
Outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share
Number of dilutive securities excluded in the calculation of diluted net loss per share		76,041	86,090
Common stock
Outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share
Obligation to issue warrants, in shares		93,341
Series A-3 Preferred Stock
Outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share
Obligation to issue warrants, in shares			300,000	300,000