SCHEDULE 13G 0001502725 XXXXXXXX LIVE Common Stock, $0.01 par value 09/29/2025 0000318306 ABEONA THERAPEUTICS INC. 00289Y206 6555 Carnegie Avenue, 4thFloor Cleveland OH 44103 Rule 13d-1(c) NANTAHALA CAPITAL PARTNERS LIMITED PARTNERSHIP MA 0.00 2618462.00 0.00 2618462.00 2618462.00 N 5.09 PN ABEONA THERAPEUTICS INC. 6555 Carnegie Avenue, 4thFloor, Cleveland, OH, 44103 NANTAHALA CAPITAL PARTNERS LIMITED PARTNERSHIP ("Nantahala") 130 Main St. 2nd Floor, New Canaan, CT 06840 Nantahala is a Massachusetts limited partnership. Y As of September 29, 2025, Nantahala may be deemed to be the beneficial owner of 2,618,462 Shares. The 2,618,462 Shares includes 179,832 Shares which may be acquired by the Reporting Persons within sixty days through the exercise of securities. As of September 29, 2025 each of the Reporting Persons may be deemed to be the beneficial owner of 5.09% of the total number of Shares outstanding, based on 51,278,539 shares outstanding received from the issuer on August 14, 2025 10-Q June 30, 2025 in addition to 179,832 Shares which may be acquired by the Reporting Persons within sixty days through the exercise of securities. 0 2,618,462 0 2,618,462 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. NANTAHALA CAPITAL PARTNERS LIMITED PARTNERSHIP /s/ Taki Vasilakis 10/06/2025 /s/ Wilmot B. Harkey 10/06/2025 /s/ Daniel Mack 10/06/2025