X0306 4 2020-12-16 0 0001501989 CytomX Therapeutics, Inc. CTMX 0001664708 Mohindru Mani C/O CYTOMX THERAPEUTICS, INC. 151 OYSTER POINT BLVD., STE. 400 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Stock Option (Right to Buy) 7.45 2020-12-16 4 A 0 40000 0.00 A 2030-12-15 Common Stock 40000 40000 D 1/36th of the shares subject to the option vest on each monthly anniversary measured from December 16, 2020 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date. /s/ Lloyd Rowland, as Attorney-in-Fact for Mani Mohindru 2020-12-18