X0306 4 2019-02-14 0 0001501756 Adverum Biotechnologies, Inc. ADVM 0001698816 Cheng Jennifer C. C/O ADVERUM BIOTECHNOLOGIES, INC. 1035 O'BRIEN DRIVE MENLO PARK CA 94025 0 1 0 0 General Counsel Stock Option (Right to Buy) 3.50 2019-02-14 4 A 0 80000 0.00 A 2028-02-13 Common Stock 80000 80000 D Twenty-five percent (25%) of the total number of shares subject to the option vest and become exercisable on the first anniversary of February 14, 2019 (the "Vesting Commencement Date"), and 1/48 of the total number of shares subject to the option vest and become exercisable each month thereafter, such that all of the shares subject to the option shall become vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service with the Issuer on each such vesting date. /s/ Jennifer Cheng 2019-02-19