License, Collaboration, and Funding Agreements - Genzyme Agreement (Details)	3 Months Ended	12 Months Ended
	Mar. 31, 2025 USD ($)	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Payment on obligation under license agreement		$ 7,000,000	$ 5,000,000
Collaborative arrangement, rights and obligations, cumulative net sales threshold three		$ 300,000,000
Collaborative Arrangement Transaction Statement Of Income Or Comprehensive Income Extensible Enumeration Not Disclosed Flag		false
Genzyme Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments		$ 13,000,000.0
Collaborative Arrangement, Rights and Obligations, Maximum Aggregate Milestone Payments, Remaining		3,000,000
Collaborative arrangement, rights and obligations, maximum aggregate milestone payments		5,000,000
Collaborative arrangement, rights and obligations, one time payment one		500,000
Collaborative arrangement, rights and obligations, one time payment two		1,500,000
Collaborative arrangement, rights and obligations, one time payment three		3,000,000
Collaborative arrangement, rights and obligations, cumulative net sales threshold one		50,000,000
Collaborative arrangement, rights and obligations, cumulative net sales threshold two		150,000,000
Collaborative arrangement, sales-based milestone payments accrued		$ 500,000
Genzyme Agreement | Subsequent Event
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments	$ 3,000,000.0
Genzyme Agreement | 6% Net Sales
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue, performance obligation, percentage of net sale (percent)		0.06
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer		$ 150,000,000
Genzyme Agreement | 10% Net Sales
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue, performance obligation, percentage of net sale (percent)		0.10
Genzyme Agreement | 10% Net Sales | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer		$ 150,000,000
Genzyme Agreement | 10% Net Sales | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer		$ 300,000,000
Genzyme Agreement | 12% Net Sales
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue, performance obligation, percentage of net sale (percent)		0.1200
Genzyme Agreement | 12% Net Sales | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer		$ 300,000,000
Genzyme Agreement | 15% Sublease Payments Received
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue, performance obligation, percentage of net sale (percent)		0.15