License, and Funding Agreements - Additional Information (Detail)	3 Months Ended		9 Months Ended
	Sep. 30, 2024 USD ($)	Sep. 30, 2023 USD ($)	Sep. 30, 2024 USD ($)	Sep. 30, 2023 USD ($)
Collaboration License And Funding Arrangements [Line Items]
Other income, net	$ 226,000	$ 17,000	$ 475,000	$ 342,000
Research and Development Incentive
Collaboration License And Funding Arrangements [Line Items]
Grant receivable	1,100,000		1,100,000
Other income, net			500,000	$ 400,000
Genzyme Agreement
Collaboration License And Funding Arrangements [Line Items]
Milestone Payments			13,000,000
Collaborative arrangement, rights and obligations, maximum aggregate milestone payments, per product	$ 7,000,000		7,000,000
Collaborative arrangement, rights and obligations, maximum aggregate milestone payments, remaining			3,000,000.0
Collaborative arrangement, rights and obligations, maximum aggregate milestone payments			5,000,000.0
Collaborative arrangement, rights and obligations, one time payment one			500,000
Collaborative arrangement, rights and obligations, one time payment two			1,500,000
Collaborative arrangement, rights and obligations, one time payment three			3,000,000.0
Collaborative arrangement, rights and obligations, cumulative threshold one			50,000,000.0
Collaborative arrangement, rights and obligations, cumulative threshold two			150,000,000.0
Collaborative arrangement, rights and obligations, cumulative net sales threshold three			$ 300,000,000.0
Genzyme Agreement | 6% Net Sales
Collaboration License And Funding Arrangements [Line Items]
Revenue, performance obligation, percentage of net sale	0.06		0.06
Revenue from collaborative arrangement, excluding revenue from contract with customer			$ 150,000,000
Genzyme Agreement | 10% Net Sales
Collaboration License And Funding Arrangements [Line Items]
Revenue, performance obligation, percentage of net sale	0.10		0.10
Genzyme Agreement | 10% Net Sales | Minimum
Collaboration License And Funding Arrangements [Line Items]
Revenue from collaborative arrangement, excluding revenue from contract with customer			$ 150,000,000
Genzyme Agreement | 10% Net Sales | Maximum
Collaboration License And Funding Arrangements [Line Items]
Revenue from collaborative arrangement, excluding revenue from contract with customer			$ 300,000,000
Genzyme Agreement | 12% Net Sales
Collaboration License And Funding Arrangements [Line Items]
Revenue, performance obligation, percentage of net sale	0.12		0.12
Revenue from collaborative arrangement, excluding revenue from contract with customer			$ 300,000,000