License, Collaboration, and Funding Agreements - Genzyme Agreement (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Payment on obligation under license agreement		$ 900,000
Genzyme Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments	$ 25,000,000
Payment on obligation under license agreement	$ 0		$ 0