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Preferred and Common Stock Warrants (Tables)
 12 Months Ended
Dec. 31, 2022
Derivative Instruments and Hedging Activities Disclosure [Abstract]  
Schedule of Outstanding Warrants Table The following table provides a roll forward of outstanding warrants and pre-funded warrants for the purchase of shares of the Company’s common stock for the three years ended December 31, 2022:

Number of warrants

Weighted
Average
Exercise
Price

Weighted
Average
Contractual
Term (Years)
Outstanding and exercisable as of December 31, 202013,354,403 

$13.52 

3.72
Issued2,058,032 



Exercised(2,130,000)
Expired(25.275)
Outstanding and exercisable as of December 31, 202113,257,160 

$7.96 

2.72
Issued104,531,257 
Exercised(500,100)
Expired(5,416,567)
Outstanding and exercisable as of December 31, 2022111,871,750 $1.86 4.53
Schedule of Stockholders' Equity Note, Warrants or Rights As of December 31, 2022, the Company’s outstanding warrants and pre-funded warrants to purchase shares of common stock consisted of the following:
Issuance Date

Number of Shares of Common
Stock Issuable

Exercise
Price

Expiration Date
October 25, 20165,155 

$19.78 

October 24, 2026
December 28, 2017115,916 

$19.78 

December 28, 2027
September 12, 201820,220 

$19.78 

September 12, 2028
October 19, 201820,016 

$19.78 

October 19, 2028
March 13, 20195,000 

$19.78 

March 12, 2029
April 16, 20193,866,154 

$13.20 

April 15, 2024
November 29, 20191,250,000 $12.00 (a)n/a
March 23, 202150,000 $8.70 (b)n/a
November 9, 20212,008,032 $4.98 (c)n/a
March 3, 2022766,666 $1.80 (d)n/a
July 6, 202213,276,279 $1.095 (e)n/a
July 6, 202250,925,365 $1.095 July 6, 2027
December 9, 202232,762,947 $1.50 December 9, 2027
December 9, 20226,800,000 $1.10 (f)n/a

111,871,750 


(a) In November 2019, the Company received $11.999 per pre-funded warrant, or $21.0 million in aggregate proceeds. Each pre-funded warrant may be exercised for an additional $0.001 per pre-funded warrant; (b) In March 2021, the Company received $8.69 per pre-funded warrant, or $435 thousand in aggregate proceeds. Each pre-funded warrant may be exercised for an additional $0.01 per pre-funded warrant; (c) In November 2021, the Company received $4.97 per pre-funded warrant, or $10.0 million in aggregate proceeds. Each pre-funded warrant may be exercised for an additional $0.01 per pre-funded warrant; (d) In March 2022, the Company received $1.79 per pre-funded warrant, or $1.40 million in aggregate proceeds. Each pre-funded warrant may be exercised for an
additional $0.01 per pre-funded warrant; (e) In July 2022, the Company received $1.094 per pre-funded warrant, or $14.5 million in aggregate proceeds. Each pre-funded warrant may be exercised for an additional $0.001 per pre-funded warrant; and (f) In December 2022, the Company received $1.099 per pre-funded warrant, or $7.5 million in aggregate proceeds. Each pre-funded warrant may be exercised for an additional $0.001 per pre-funded warrant.