Common Stock Warrants - Summary of Outstanding Warrants to Purchase Shares of Common Stock (Detail) - USD ($) $ / shares in Units, $ in Thousands	Mar. 31, 2022	Mar. 03, 2022	Dec. 31, 2021	Nov. 09, 2021	Mar. 23, 2021	Nov. 02, 2020	Nov. 29, 2019
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	14,023,726		13,257,160
Class Of Warrant Or Right. Aggregate Proceeds From Warrants Issued		$ 3,000		$ 10,000	$ 435		$ 21,000
Class of Warrant or Right, Additional Exercise Price of Warrants or Rights					$ 0.01	$ 0.01	$ 0.001
Funded
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)		$ 1.79		$ 4.97	$ 8.69
Pre Funded Warrant
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)							11.999
Class B Warrants
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)							$ 15.00
Issuance On October 25, 2016
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)	$ 19.78
Issuance On October 25, 2016 | Legacy Warrants
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	5,155
Issuance On December 28, 2017 One
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)	$ 19.78
Issuance On December 28, 2017 One | Legacy Warrants
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	115,916
Issuance On September 12, 2018 One
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)	$ 19.78
Issuance On September 12, 2018 One | Legacy Warrants
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	20,220
Issuance On October 19, 2018
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)	$ 19.78
Issuance On October 19, 2018 | Legacy Warrants
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	20,016
Issuance On March 13, 2019
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)	$ 19.78
Issuance On March 13, 2019 | Legacy Warrants
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	5,000
Issuance On April 16, 2019
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)	$ 13.20
Issuance On April 16, 2019 | Class A Warrant
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	3,866,154
Issuance On November 29, 2019
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)	$ 1.80
Issuance On November 29, 2019 | Class B Warrants
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	5,416,567
Issuance On November 29, 2019 One
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)	$ 12.00
Issuance On November 29, 2019 One | Pre Funded Warrant
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	1,750,000
Issuance On March 23, 2021
Class of Warrant or Right [Line Items]
Exercise Price (usd per share)	$ 8.70
Issuance On March 23, 2021 | Pre Funded Warrant
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	50,000
Issuance on November Nine Two Thousand Twenty One
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	2,008,032
Exercise Price (usd per share)	$ 4.98
Issuance on March 3 2022
Class of Warrant or Right [Line Items]
Number of Shares of Common Stock Issuable (in shares)	766,666
Exercise Price (usd per share)	$ 1.80