Exhibit 12.1

CERTIFICATION OF THE CHIEF EXECUTIVE OFFICER UNDER SECTION 302 OF THE

SARBANES-OXLEY ACT

I, Philip A. Serlin, certify that:

1. I have reviewed this Amendment No. 1 to the Annual Report (the “Report”) on Form 20-F of BioLineRx Ltd. and

2. Based on my knowledge, this Report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this Report.

Date: June 5, 2019

/s/  Philip A. Serlin          

Philip A. Serlin

Chief Executive Officer