X0101 EFFECT 33 LIVE 2012-11-01 0001445546-12-004351 485APOS 0001497778 FIRST TRUST SERIES FUND 333-168727 S000038285 First Trust Short Duration High Income Fund C000118178 Class A S000038285 First Trust Short Duration High Income Fund C000121471 Class C S000038285 First Trust Short Duration High Income Fund C000121472 Class I