X0101 EFFECT 33 LIVE 2011-01-11 09:30:00

N-1A

0001497778 FIRST TRUST SERIES FUND 333-168727 S000030198 First Trust Preferred Securities and Income Fund C000092932 Class A S000030198 First Trust Preferred Securities and Income Fund C000092933 Class C S000030198 First Trust Preferred Securities and Income Fund C000092934 Class F S000030198 First Trust Preferred Securities and Income Fund C000092935 Class I S000030198 First Trust Preferred Securities and Income Fund C000092936 Class R3 S000030199 First Trust/Confluence Small Cap Value Fund C000092937 Class R3 S000030199 First Trust/Confluence Small Cap Value Fund C000092938 Class A S000030199 First Trust/Confluence Small Cap Value Fund C000092939 Class C S000030199 First Trust/Confluence Small Cap Value Fund C000092940 Class F S000030199 First Trust/Confluence Small Cap Value Fund C000092941 Class I