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            <dateOfFirstSale>
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            <clarificationOfResponse>The issuer issues profit interests ($0 initial value).</clarificationOfResponse>
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                <issuerName>Knopp Biosciences LLC</issuerName>
                <signatureName>/s/ Gregory T. Hebrank</signatureName>
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                <signatureTitle>EVP, Corporate Operations &amp; Finance</signatureTitle>
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