Note 7 - Stockholders Equity - Stock Option Activity (Details) - USD ($)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Outstanding, number of units, beginning balance (in shares)	691,374	691,374
Outstanding, weighted average exercise price, beginning balance (in dollars per share)	$ 12.44	$ 12.44
Outstanding, weighted average remaining contractual term (Year)	7 years 306 days	8 years 226 days	8 years 226 days
Outstanding, aggregate intrinsic value	$ 90,097
Granted, number of units (in shares)	283,372
Granted, weighted average exercise price (in dollars per share)	$ 6.75
Granted, weighted average remaining contractual term (Year)
Options from Dipexium, number of units (in shares)	191,963
Options from Dipexium, weighted average exercise price (in dollars per share)	$ 57.94
Options from Dipexium, weighted average remaining contractual term (Year)
Cancelled, number of units (in shares)
Outstanding, number of units, ending balance (in shares)	1,166,709	691,374	691,374
Outstanding, weighted average exercise price, ending balance (in dollars per share)	$ 18.54	$ 12.44	$ 12.44
Exercisable, number of units (in shares)	888,124
Exercisable, weighted average exercise price (in dollars per share)	$ 21.71
Exercisable, weighted average remaining contractual term (Year)	7 years 175 days
Exercisable, aggregate intrinsic value	$ 15,637