X0306 4 2018-05-24 0 0001497253 ORGANOVO HOLDINGS, INC. ONVO 0001621152 Bush Jennifer 6275 NANCY RIDGE DRIVE, SUITE 110 SAN DIEGO CA 92121 0 1 0 0 General Counsel & Secretary Common Stock 2018-05-24 4 A 0 70248 0.00 A 305903 D Stock Option (Right to Buy) 1.84 2018-05-24 4 A 0 283333 0.00 A 2028-05-24 Common Stock 283333 283333 D Annual long-term equity award approved by the Compensation Committee of the Issuer's Board of Directors. The shares represent a grant of Restricted Stock Units ("RSUs"). The RSUs represent a right to receive shares of the Issuer's common stock, at no additional conversion or exercise price. The RSUs vest and settle over 16 equal quarterly installments measured from May 15, 2018. This number does not include 658,333 shares of common stock underlying outstanding options held by Ms. Bush; post-transaction Ms. Bush beneficially owns or has a right to acquire 964,236 shares of common stock. The option shares vest and become exercisable over 16 equal quarterly installments measured from May 15, 2018. /s/ Jennifer Bush 2018-05-29