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Equity Incentive Plans - Additional Information (Details) - USD ($)
1 Months Ended 12 Months Ended
Jan. 03, 2022
Jan. 20, 2021
Sep. 30, 2014
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2010
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Shares of common stock are subject to options outstanding       8,324,000 8,637,000    
Common stock fair value       $ 0.67      
Weighted-average grant date fair value of options       $ 2.07 $ 5.09 $ 3.46  
Total fair value of options vested       $ 9,400,000 $ 6,900,000 $ 6,700,000  
Aggregate intrinsic value of options exercised       $ 23,000 $ 200,000 $ 300,000  
Weighted-average remaining contractual term, exercisable options       4 years 11 months 15 days      
Weighted-average remaining contractual term, vested and expected to vest options       6 years 1 month 24 days      
Unrecognized compensation expense related to unvested awards       $ 8,900,000      
Weighted-average period to recognize compensation expense       2 years 4 months 13 days      
Number of stock awards issued       2,190,000      
Grant date fair value of stock awards       $ 2.94      
Number of stock vested       1,069,000      
Employee Stock Purchase Plan              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Equity compensation plan, common stock outstanding percentage     1.00%        
Number of shares available for issuance       680,893      
Equity compensation plan, outstanding shares     250,000        
Percentage of discount through payroll deductions to eligible employees to purchase common stock       15.00%      
Percentage of fair value of common stock       85.00%      
Shares of common stock issued to employees       1,085,757      
RSUs              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Option vesting, year       4 years      
Number of stock awards issued       582,056 0    
Annual stock awards vesting percentage       25.00%      
Fair value of other than options vested       $ 3,200,000      
Number of stock vested         0    
PSUs              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Number of stock awards issued   1,607,812          
Grant date fair value of stock awards   $ 2.98          
Expense related to PSUs       $ 3,900,000      
PSUs | Subsequent Event              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Annual stock awards vesting percentage 20.00%            
Stock awards vesting percentage upon achievement of two goals 80.00%            
2010 Equity Incentive Plan              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Percentage of voting rights             10.00%
Minimum exercise price of incentive stock options             110.00%
Option granted, year             10 years
Option vesting, year             4 years
Shares of common stock are subject to options outstanding       365,000      
2014 Equity Incentive Plan              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Option granted, year       10 years      
Option vesting, year       4 years      
Equity compensation plan, common stock outstanding percentage     4.00%        
Common stock reserved for issuance       11,600,000      
Number of shares available for issuance       1,821,000      
2018 Inducement Plan              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Option granted, year       10 years      
Option vesting, year       4 years      
Common stock reserved for issuance       1,000,000      
Number of shares available for issuance       811,000