Organization and Basis of Presentation - Additional Information (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($) Segment	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Mar. 29, 2022 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
State of incorporation	DE
Date of incorporation	Mar. 09, 2010
Number of operating segments | Segment	1
Cash and cash equivalents	$ 59,537	$ 107,146
Accumulated deficit	491,326	376,238
Loss from continuing operations	(115,088)	(90,137)	$ (89,860)
Cash used in operations	$ (66,300)	$ (84,312)	$ (78,745)
Underwriting Agreement | Subsequent Event
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Gross proceeds from public offering				$ 10,000