X0306 4 2021-01-20 0 0001496671 Calithera Biosciences, Inc. CALA 0001670740 Orford Keith C/O CALITHERA BIOSCIENCES, INC. 343 OYSTER POINT BLVD. #200 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 CHIEF MEDICAL OFFICER Common Stock 2021-01-20 4 A 0 35000 0.00 A 46094 D Common Stock 2021-01-20 4 A 0 30000 0.00 A 76094 D Employee Stock Option (Right to Buy) 2.98 2021-01-20 4 A 0 150000 0.00 A 2031-01-20 Common Stock 150000 150000 D The shares of Common Stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall vest as follows: one-fourth (1/4th) of the shares subject to the Restricted Stock Unit will vest each year after January 20, 2021 until the Restricted Stock Units are fully vested. The Restricted Stock Unit shall be subject to accelerated vesting as set forth in the optionee's employment agreement with the Company. The shares of Common Stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall fully vest on January 3, 2022. The Restricted Stock Unit shall be subject to accelerated vesting as set forth in the optionee's employment agreement with the Company. One-fourth (1/4th) of the Option vests one year after January 20, 2021; the balance of the Option vests in a series of thirty-six (36) successive equal monthly installments thereafter. The Option shall be subject to accelerated vesting as set forth in the optionee's employment agreement with the Company. /s/ Keith Orford 2021-01-22